Popular weight loss drugs like Zepbound and Wegovy are GLP-1 receptor agonist medications, and they are a game-changer in weight management. But weight loss is only part of the story. With different brand names, these medications are also expanding how doctors manage heart disease and support healthier outcomes.

GLP-1 medications offer benefits for people with diabetes, weight management challenges and heart disease. If you’re not familiar with how these drugs can help with heart disease, call (847) 425-6400 to schedule an appointment with your doctor.

History of GLP-1 medications

GLP-1 medications were first introduced in 2005 to treat diabetes. Doctors soon noticed improvements in weight, cholesterol and blood pressure, leading to their use for weight management starting in 2014. Over time, studies showed better heart outcomes, even in patients without diabetes.

How GLP-1 medications support heart health

These medications help the heart muscle relax and improve how the heart fills with blood, which supports healthier circulation. They have been shown to lower the risk of heart attack and reduce hospitalizations for heart failure. For many patients, this can mean fewer serious heart events over time.

What to expect when starting GLP-1 medications

Doctors start GLP-1 medications slowly to reduce the risk of side effects like nausea. Most patients use a once-weekly pen injection, beginning with a low dose that increases gradually over several weeks. This careful approach helps your body adjust while maximizing benefits.

Endeavor Health offers a cardiometabolic clinic to help patients choose the best medication for their needs. Cardiologists often start patients on these medications as part of heart disease prevention. GLP-1 medications work best when they are part of a long-term plan, not a short-term fix.

A broader prevention strategy

GLP-1 medications are one piece of a larger heart health strategy. Diet, exercise and healthy daily habits are essential for lasting results. These medications work best when paired with lifestyle changes.

Nutrition goals often include higher fiber, lower fat and lower sodium choices. Because GLP-1 medications can contribute to muscle loss, resistance and strength training are important to help preserve muscle and support overall health.

Important things to remember

If you are scheduled for surgery, tell your care team if you are taking a GLP-1 medication. These drugs affect digestion and may require stopping the medication about a week before surgery. Your care team will guide you on safe timing.

GLP-1 medications slow digestion to help you feel full longer. This can sometimes cause nausea, especially if meals are too large or doses increase too quickly. Your doctor will guide you in adjusting portions and pacing dose changes to help you feel better while staying on track.

Improving your heart health

Endeavor Health continues to use new tools and therapies to improve heart health and patient outcomes. GLP-1 medications are another way physicians can help protect your heart and overall wellbeing. Call (847) 425-6400 or schedule an appointment with our cardiometabolic clinic or with one of our cardiologists.

Back to top