Metastatic cancer was once a death sentence, but thanks to tremendous advances in immunotherapy and ongoing research in the field of oncology, people with advanced cancer are living many years with good quality of life.

“We live in a blessed era,” said Amin Kassam, MD, neurosurgeon at Endeavor Health, who is at the forefront of helping patients with metastatic brain and spine cancer preserve their personality, speech, movement, thought, and more through sophisticated minimally-invasive brain surgery performed while patients are fully conscious.

“Immune therapy has made many cancers a chronic disease,” said Dr. Kassam. “Survival is dependent on the host organ — breast, lung, where the cancer originated, but quality of life is largely determined by the brain. It’s my responsibility in surgery to preserve quality of life at all costs.”

Cancer is a smart, genetically-coded, living organism that disguises its cells, attacking and destroying healthy cells and organs, but in the last decade researchers have figured out how to unmask many of those cancer cells, targeting them with specific therapies, explained Dr. Kassam.

“Only a handful of those masks remain and through the advent of AI, with incredibly large volumes of information processed simultaneously, we will find those masks and develop effective, targeted approaches. Ultimately, we will unmask cancer and our immune system will treat it minute-to-minute” said Dr. Kassam.
 

Research and innovation

Endeavor Health has a long history of pioneering research that drives advancements in patient care.

Like many physician-scientists, Dr. Kassam’s journey in research began with the development of clinical trials, and he is one of the most widely published neurosurgeons. However, he is now most excited about research that aims to understand each individual patient’s cancer story.

“AI provides the limitless ecosystem that allows us to access all the world’s knowledge and design individual therapeutic treatments for patients.”

Dr. Kassam and the multidisciplinary team caring for brain and spine cancer patients are drawing referrals from around the country. Dr. Kassam is able to remove tumors through a tiny port the size of a dime, while patients are not only awake but truly conscious and talking during the procedure to ensure that brain function and their ability to think, laugh etc. are preserved.

Many patients have focused beam radiation or radiosurgery to help treat tumors before surgical resection, while others are treated with radiosurgery alone.

“Our patients today are often not waiting for a clinical trial. We’re using their molecular data to help guide more targeted, systemic treatments in conjunction with local therapies like surgery and radiosurgery,” said Endeavor Health radiation oncologist Stephen Nigh, MD. Patients are cared for by a collaborative team of specialists in the dedicated brain and spine clinic.

“We are seeing patients who even five years ago might have lived three to five months, and now they are many years out with metastatic cancer and enjoying a very good quality of life,” added Dr. Nigh. “These are remarkable outcomes and it’s one of the most explosive areas of research and innovation; it’s a very exciting time.”

“My goal is to continue to use individualized, science-based therapeutics to preserve quality of life for each patient,” said Dr. Kassam.

“Our agenda is not to find the right patient to fit the right available trial and then to have them randomized as to whether they get treatment or not. Our objective is to find the right treatment based on the best available science and the world’s cumulative knowledge — everything the world has learned ever and everywhere — to then bring that to each patient.”

“Each patient has their own story, and we need to listen. It’s their story, not ours. We have assembled the right team here to provide extraordinary care,” he added.

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