Comprehensive care for hepatobiliary cancer

Hepatobiliary cancers affect the bile ducts and gallbladder — organs critical to digestion and detoxification. These cancers are uncommon but often aggressive, requiring highly coordinated care. At Endeavor Health, our multidisciplinary team specializes in diagnosing and treating these cancers with advanced tools, minimally invasive techniques and personalized treatment planning.

We provide access to leading-edge surgical options, interventional radiology, targeted and immunotherapies and integrated support services, helping you navigate each step with confidence.

Understanding hepatobiliary cancer

Hepatobiliary cancers include:

  • Bile duct cancer (cholangiocarcinoma): Affects the bile ducts, which carry bile from the liver to the intestine
  • Gallbladder cancer: Rare but aggressive; often diagnosed late due to subtle symptoms

These cancers require early, expert intervention. Our team also has expertise in innovative techniques to treat metastatic cancers that have spread to the liver.

Hepatobiliary cancer symptoms

Symptoms can vary based on tumor location but may include:

  • Jaundice (yellowing of the skin and eyes)
  • Abdominal pain or swelling
  • Loss of appetite or weight loss
  • Nausea or vomiting
  • Dark urine and pale stools
  • Fever or night sweats

If you notice persistent symptoms, talk to your doctor about next steps.

Hepatobiliary cancer treatment and therapies

Surgery may involve bile duct resection or cholecystectomy (gallbladder removal). Our team specializes in minimally invasive and robotic-assisted approaches.

Techniques like radiofrequency ablation and Y-90 radioembolization destroy or limit tumors without surgery.

Catheter-based treatments deliver chemotherapy or radiation directly to tumors with fewer side effects.

Targeted therapies and immunotherapies are used for advanced or metastatic disease, guided by molecular profiling.

Hepatobiliary cancer tests and screenings

There are no standard screening guidelines for most hepatobiliary cancers. But those with chronic liver disease may benefit from regular monitoring.

Common diagnostics include:

Liver function tests and tumor markers (e.g., alpha-fetoprotein)

Ultrasound, CT, MRI or angiogram to visualize tumors and structures

EUS or ERCP for bile duct evaluation

Confirms diagnosis and supports genetic analysis

Why Endeavor Health?

At Endeavor Health, we offer expert hepatobiliary cancer care with advanced technology and whole-person support.

Our fellowship-trained hepatobiliary use minimally invasive techniques to reduce recovery time and improve outcomes. If you would benefit from liver transplantation, we partner with leading transplant programs in the area.

Your case is reviewed in a multidisciplinary conference to design a coordinated care plan.

Y-90 radioembolization, embolization and ablation options are available through interventional radiology.

We provide financial advocacy, nurse navigation, nutrition guidance and survivorship services to support your care journey.

Care team

Our hepatobiliary specialists include GI and hepatobiliary surgeons, medical oncologists, interventional radiologists, radiation oncologists, pathologists, genetic counselors, nurse navigators, social workers and registered dietitians.

Find a doctor

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Hepatobiliary cancer FAQs

Jaundice, abdominal pain, and unexplained weight loss may signal liver, bile duct or gallbladder cancer.

For cancers that have not spread, some may be curable with surgery or transplantation, often with the help of other therapies. Advanced cancers are managed with long-term treatment strategies.

Our experts offer targeted therapy, immunotherapy, interventional radiology and ablation, among other options, depending on your cancer type.

You’ll receive nurse navigation, nutrition services, integrative medicine, financial support and follow-up care.

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If you've been diagnosed with a bile duct or gallbladder tumor — or need a second opinion — our experts are here to help.

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Your care journey is our mission

The Endeavor Health Cancer Institute is committed to delivering compassionate, cutting-edge care for hepatobiliary cancers, offering personalized treatments and multidisciplinary support close to home.

About the institute